Preparation and Application of Perchloric Acid Supported on Alumina (Al2O3-HClO4) to the Synthesis of α-(α-Amidobenzyl)-β-naphthols

Preparation of perchloric acid supported on alumina and its primary application as a solid supported heterogeneous catalyst to the synthesis of alpha-(alpha-amidobenzyl)-beta-naphthols by a one-pot, three-component condensation of benzaldehydes, beta-naphthol and acetamide or benzamide under thermal solvent-free conditions were described. The present methodology offers several advantages such as simple procedure, shorter reaction time, and excellent yields.