Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 27, Issue 12, Pages 2418-2422Publisher
WILEY-BLACKWELL
DOI: 10.1002/cjoc.201090018
Keywords
2-substituted-1,2,3,4-tetrahydro-4-quinazolinone; PPA-SiO2; solvent-free; heterogeneous catalyst; silica-supported polyphosphoric acid (PPA-SiO2)
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Funding
- Sistan and Baluchestan University Research Council
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Silica-supported polyphosphoric acid (PPA-SiO2) catalyzed efficiently the reaction of anthranilamide with aryl aldehydes or ketones under solvent-free conditions to afford the corresponding 1,2,3,4-tetrahydro-4-quinazolinone derivatives. This work consistently has the advantages of excellent yields, short reaction time, simple experimental and work-up procedures. The heterogeneous catalyst could be recovered and recycled for several times without any loss of its activity.
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