Journal
CHINESE CHEMICAL LETTERS
Volume 25, Issue 4, Pages 589-592Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.01.019
Keywords
Bis-benzimidazole; Anti-tumor; DNA minor groove
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Funding
- Wuhan City Department of Education [20091(106)]
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A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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