Journal
CHINESE CHEMICAL LETTERS
Volume 25, Issue 12, Pages 1531-1534Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.09.012
Keywords
Euphorbia micractina; Euphorbiaceae; Diterpenoid; Secoeuphoractin
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Funding
- National Natural Science Foundation of China (NNSFC) [21172266, 30825044]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) [IRT1007]
- National Science and Technology Project of China [2012ZX09301002-002]
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A minor diterpenoid with a novel carbon skeleton, secoeuphoractin (1), was isolated from an ethanol extract of the roots of Euphorbia micractina. Its structure including the absolute configuration was determined by extensive spectroscopic studies, especially by 2D NMR and CD data analysis, in combination with a plausible biosynthetic pathway associated with co-occurring diverse diterpenoids. This compound showed activity against HIV-1 replication with an IC50, value of 1.76 +/- 0.61 mu mol/L. (C) 2014 Jian-Gong Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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