Secoeuphoractin, a minor diterpenoid with a new skeleton from Euphorbia micractina

A minor diterpenoid with a novel carbon skeleton, secoeuphoractin (1), was isolated from an ethanol extract of the roots of Euphorbia micractina. Its structure including the absolute configuration was determined by extensive spectroscopic studies, especially by 2D NMR and CD data analysis, in combination with a plausible biosynthetic pathway associated with co-occurring diverse diterpenoids. This compound showed activity against HIV-1 replication with an IC50, value of 1.76 +/- 0.61 mu mol/L. (C) 2014 Jian-Gong Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.