4.7 Article

Design, synthesis, in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial, antifungal and anti-tubercular agents

Journal

CHINESE CHEMICAL LETTERS
Volume 23, Issue 4, Pages 446-449

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2012.01.040

Keywords

Tetrahydropyrimidines; Isatin; 1,3-Dihydro-2H-indol-2-ones; Biginelli reaction; CaCl2 catalyst; In vitro antituberculer activity; Antibacterial and antifungal activity

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A series of 5-substitued-3-(5-(4-(furan-2-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-ylimino)indolin-2-one derivatives were synthesized, characterized and were screened for anti-bacterial, anti-fungal and antitubercular activity. (C) 2012 Jignesh Priyakant Raval. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights

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