Journal
CHINESE CHEMICAL LETTERS
Volume 23, Issue 8, Pages 891-894Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2012.06.002
Keywords
Benzylic oxidation; Hypervalent iodine intermediate; Catalytic reaction; Synthesis
Categories
Funding
- Natural Science Foundation of China [21072176]
- Zhejiang Province Natural Science Foundation of China [Y4100231]
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An effective and environmentally benign benzylic oxidation for transition of alkylarenes into the corresponding carbonyl compounds was reported. Alkylarenes were mixed and stirred with potassium bromide, m-chloroperbenzoic acid and a catalytic amount of iodobenzene in water at 60 degrees C for several hours, a series of the corresponding carbonyl compounds was obtained in moderate to good yields. In the reaction, iodobenzene was first oxidized by m-chloroperbenzoic acid into the hypervalent iodine intermediate which then reacted with potassium bromide to form the key radical initiator for the benzylic oxidation. (C) 2012 Jie Yan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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