Journal
CHINESE CHEMICAL LETTERS
Volume 23, Issue 9, Pages 1015-1018Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2012.06.041
Keywords
Antimicrobial activity; Ionic liquid; Neat conditions; 8,9-Dihydro-2-(2-oxo-2H-chromen-3-yl)-5-aryl-3H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione
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Funding
- Ministry of Human Resource Development
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A series of 8,9-dihydro-2-(2-oxo-2H-chromen-3-yl)-5-aryl-3H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-diones (5a-j) have been synthesized by the reaction of 2-amino-5,6,7,8-tetrahydro-5-oxo-4-aryl-4H-chromene-3-carbonitrile (4a-j) with coumarin-3-catboxylic acid under neat conditions employing Bronsted acidic ionic liquid (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate as catalyst. Structures of all the compounds were established on the basis of analytical and spectroscopic data. All the compounds were evaluated for their in vitro antimicrobial activity against different bacterial and fungal strains. (C) 2012 Rajitha Bavanthula. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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