Journal
CHINESE CHEMICAL LETTERS
Volume 22, Issue 11, Pages 1317-1320Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2011.06.008
Keywords
Sulfamic acid; Catalyst; Anthranilamide; Aldehyde; Ketone; 2,3-Dihydroquinazolin-4(1H)-ones
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A series of 2,3-dihydroquinazolin-4(1H)-ones have been synthesized in good to excellent yields through direct cyclocondensation of anthranilamide and aryl aldehydes or ketones in water or methanol under mild conditions. The reaction was efficiently promoted by 10 mol% sulfamic acid (SA, H2NSO3H) and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity. (C) 2011 Amin Rostami. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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