Journal
CHINESE CHEMICAL LETTERS
Volume 22, Issue 6, Pages 631-634Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2010.12.039
Keywords
Cyclic peptide; Solid-phase synthesis; Cyclization; Purification; Euryjanicin B
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Funding
- National Natural Science Foundation [20902109]
- Science & Technology Commission of Shanghai Municipality [08JC1405500]
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The first synthesis of the naturally occurring cyclic peptide euryjanicin B has been achieved. A general method was described to synthesize the cyclic peptide by a two-step solid-phase/solution synthesis strategy. All the amino acids in this study are L-configuration, The linear heptapeptide was assembled by standard Fmoc chemistry on solid-phase and subsequently cyclization was carried out by solution method. (C) 2011 Hong Gang Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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