Journal
CHINESE CHEMICAL LETTERS
Volume 22, Issue 9, Pages 1059-1062Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2011.03.012
Keywords
Water; Alum; 3,4,6-Trisubstituted 2-pyridone; Click reaction
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An efficient green protocol for the preparation 3,4,6-trisubstituted 2-pyridone of employing a condensation reaction of cyanoacetamide and acetylacetone in the presence of KAl(SO4)(2)center dot 12H(2)O in water has been described. The present procedure offers advantage such as shorter reaction time, simple workup, and excellent yields. (C) 2011 Majid M. Heravi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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