Journal
CHINESE CHEMICAL LETTERS
Volume 22, Issue 9, Pages 1123-1126Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2011.04.005
Keywords
Micelle; Thermo-sensitive; Drug; Hydrogen-bonding; Poly (N-isopropylacrylamide)
Categories
Funding
- NSFC [20674069]
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Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly (N-isopropylacrylamide). Only ibuprofen could induce the formation of drug loaded micelles, which was confirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly (N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found that the diameter of the ibuprofen-loaded micelles changed reversibly against temperature. (C) 2011 Li Qun Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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