Journal
CHINESE CHEMICAL LETTERS
Volume 22, Issue 8, Pages 899-902Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2011.01.010
Keywords
Pyrimidine nucleoside; NO-donor; Antivirus; Furoxans; Oximes; Synthesis
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Funding
- National Natural Science Foundation of China [30572240]
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New pyrimidine nucleoside derivatives with nitric oxide (NO) donor were systematically synthesized. The antivirus activities of these nucleoside analogues against vesicular stomatitis virus (VSV) in Wish cell were evaluated. It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir, while their toxicities were similar or lower to acyclovir. (C) 2011 Qi Zheng Yao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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