Journal
CHINESE CHEMICAL LETTERS
Volume 22, Issue 8, Pages 923-926Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2011.01.038
Keywords
Aza-Henry reaction; Thiourea; Guanidine; Nitroacetate; Organocatalysis
Categories
Funding
- Sichuan Provincial Education Department [310-347]
- Technology Department of Chengdu University of TCM [310-446, 310-448]
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The asymmetric aza-Henry reaction of a-substituted nitroacetates and N-Boc imines was achieved with a new-type thiourea-guanidine bifunctional organocatalyst. The novel transformations exhibited high diastereoselectivities, and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities (up to 88% ee). (C) 2011 Wei Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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