Journal
CHINESE CHEMICAL LETTERS
Volume 21, Issue 9, Pages 1087-1090Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2010.04.020
Keywords
Solasodine; Derivatives; In vitro anticancer
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Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50 = 3.91 mu mol/L). (C) 2010 Jun O. Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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