Journal
CHINESE CHEMICAL LETTERS
Volume 21, Issue 11, Pages 1295-1298Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2010.04.034
Keywords
Perkin reaction; 3-Arylcoumarin; Trans-stilbene; Antitumor activity
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Funding
- National Key Technology RD Program
- Science and Technology Program of Guangdong Province
- Guangdong Province [2007BAD82B02, 2006B35604002, 2009B091300125]
- Chinese Academy of Sciences, PR China [2007BAD82B02, 2006B35604002, 2009B091300125]
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A series of novel coumarin-stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents. The results showed that some compounds exhibited in vitro activity against KB, KV, MCF-7, MCF-7/ADR cell lines to some extent. Compound 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18 mu mol/L. (C) 2010 Yong Zou. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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