Journal
CHINESE CHEMICAL LETTERS
Volume 20, Issue 4, Pages 404-406Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2008.12.009
Keywords
Oxadiazolo[3,4-d]pyrimidine nucleoside; Antivirus; Synthesis
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Funding
- National Natural Science Foundation of China [30572240]
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A series of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides was designed, synthesized and evaluated against vesicular stomatitis virus (VSV) in Wish cell. The antiviral activities of all compounds were stronger than those of acyclovir, while their toxicities were similar to those of acyclovir. (C) 2008 Qi Zheng Yao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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