Journal
CHINESE CHEMICAL LETTERS
Volume 19, Issue 10, Pages 1163-1166Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2008.06.052
Keywords
Cinnamide derivatives; Synthesis; Neuroprotective; Edaravone
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Funding
- Natural Science Foundation of Education Department of Jiangsu Province [05KJB350084]
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A new series of compounds (E)-1-(4-(bis-arylmethyl)piperazin-1-yl)-3-arylprop-2-en-1-one (1a-r), have been synthesized and their structures were confirmed by ESI-MS and (1)H NMR. The preliminary pharmacological screening showed that some of these compounds had similar neuroprotective effects with Edaravone. (C) 2008 Bin Wu. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.
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