4.7 Article

Synthesis and neuroprotective properties of novel cinnamide derivatives

Journal

CHINESE CHEMICAL LETTERS
Volume 19, Issue 10, Pages 1163-1166

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2008.06.052

Keywords

Cinnamide derivatives; Synthesis; Neuroprotective; Edaravone

Funding

  1. Natural Science Foundation of Education Department of Jiangsu Province [05KJB350084]

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A new series of compounds (E)-1-(4-(bis-arylmethyl)piperazin-1-yl)-3-arylprop-2-en-1-one (1a-r), have been synthesized and their structures were confirmed by ESI-MS and (1)H NMR. The preliminary pharmacological screening showed that some of these compounds had similar neuroprotective effects with Edaravone. (C) 2008 Bin Wu. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

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