4.7 Article

Solvent- and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions

Journal

CHINESE CHEMICAL LETTERS
Volume 19, Issue 10, Pages 1183-1185

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2008.06.039

Keywords

Focused microwave-assisted; Catalyst- and solvent-free; Synthesis; Dihydropyrimidinthiones

Funding

  1. Natural Science Foundation of China [20272047, 20572086]
  2. Natural Science Foundation of Gansu Province [3ZS051-A25-001]
  3. Key Laboratory of Eco-Environment-Related Polymer Material
  4. Ministry of Education of China

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Fifteen dihydropyrimidinthiones have been synthesized by microwave-assisted Biginelli reactions without any solvent or catalyst. The advantages of this novel protocol include the excellent yield, operational simplicity, short time and the avoidance of the use of organic solvents and catalysts. (C) 2008 Jin Xian Wang. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved.

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