Journal
CHINESE CHEMICAL LETTERS
Volume 19, Issue 5, Pages 562-564Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2008.03.018
Keywords
marine fungus; eremophilane sesquiterpenes; NMR analysis; cytotoxic activity
Categories
Ask authors/readers for more resources
Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidated as 3-acetyl-9, 7 (11)-dien-7 alpha-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydroxypetasol (4), 8 alpha-hydroxy-13-deo -xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a new compound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388, A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide rings in eremophilane molecules were essential for their activity, and acetylation could enhance their activity. (C) 2008 Yong Fu Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available