Journal
CHINESE CHEMICAL LETTERS
Volume 19, Issue 12, Pages 1395-1397Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2008.09.034
Keywords
Quinolone derivatives; Synthesis; Antitumor
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Funding
- National Natural Science Foundation of China [30271543]
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A series of quinolone derivatives containing benzimidazole, benzoxazole or benzothiazole ring were synthesized. The cytotoxicity of 12 new compounds was evaluated in KB, Bel7402, A2780 and HT-29 cell lines. Most of synthesized compounds showed moderate inhibitory activity against cancer cells. The inhibitory activities of 6k, against KB and A2780 tumor cells are comparable to that of topotecan, one of topoisomerase I inhibitors. (c) 2008 Qi Dong You. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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