Journal
CHIMIA
Volume 67, Issue 12, Pages 910-915Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2013.910
Keywords
Cyclic peptides; Directed evolution; Peptides; Phage display; Therapeutics
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Funding
- Swiss National Science Foundation (SNSF) [PP00P3_123524/1]
- National Competence Center for Biomolecular Imaging (NCCBI)
- Swiss National Science Foundation (SNF) [PP00P3_123524] Funding Source: Swiss National Science Foundation (SNF)
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Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin. The success of cyclic peptide therapeutics is based on their ability to bind with high affinity, their good target selectivity and their low toxicity. As nature provides cyclic peptides to only a small number of disease targets, strategies have been developed to generate cyclic peptide ligands with tailored specificity de novo. Our laboratory is specialized on the directed evolution of bicyclic peptide ligands by phage display. In this article, we review our recent work to in vitro evolve bicyclic peptide antagonists, the binding and pharmacokinetic properties of bicyclic peptides, as well as efforts to generate bicyclic peptides for therapeutic application.
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