Journal
CHIMIA
Volume 67, Issue 4, Pages 286-290Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2013.286
Keywords
Adhesion; Biofilm; Infection; Quorum sensing; Lectins
Categories
Funding
- Zukunftskolleg
- Graduate School Chemical Biology
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
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Hospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.
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