Journal
CHIMIA
Volume 64, Issue 3, Pages 200-202Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2010.200
Keywords
Dibenzofulvene; Fmoc protection group; High-temperature NMR; Peptide synthesis; Thermal cleavage
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The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
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