Journal
CHIMIA
Volume 64, Issue 9, Pages 634-639Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2010.634
Keywords
Anti-cancer agents; Endothelial cells; Glioblastoma; alpha-Mannosidase inhibitors
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Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi alpha-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of alpha-mannosidases II able to induce antiproliferative effects in human cancer cells.
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