Journal
CHIMIA
Volume 62, Issue 10, Pages 793-798Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2008.793
Keywords
Biomaterials; Biomineralization; Polymer brushes; Protein microarrays; Surface-initiated polymerization
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Funding
- VolkswagenStiftung
- GEBERT RUF STIFTUNG
- CTI/KTI
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Surface-initiated controlled radical polymerization is a powerful strategy to tailor the chemical and physical surface properties of materials. This article highlights recent work from the author's laboratory in which surface-initiated atom transfer radical polymerization is used to generate biofunctional and biomimetic surface coatings. Three examples will be discussed. The first two examples are based on the surf ace-initiated atom transfer radical polymerization of 2-hydroxyethyl methacrylate and (polyethylene glycol) methacrylate, which generates a polymer brush that suppresses non-specific adhesion of proteins and cells. These non-fouling brushes have been used to generate protein microarrays and to produce coatings that can promote endothelialization of implantable biomaterials. The third example describes the use of polyelectrolyte brushes as matrices to direct the mineralization of calcium carbonate.
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