Journal
CHILDS NERVOUS SYSTEM
Volume 25, Issue 12, Pages 1623-1626Publisher
SPRINGER
DOI: 10.1007/s00381-009-0938-z
Keywords
Choroid plexus; Papilloma; Cytogenetic; Cancer
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Funding
- FAPESP [06/04827-3, 07/54236-4, 07/04065-9]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [06/04827-3] Funding Source: FAPESP
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Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. In the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed. CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome hybridization (CGH). Conventional karyotype analysis of tumor culture showed a normal chromosome complement. The results were confirmed by CGH, showing normal hybridization patterns for the sample. To date, the few atypical CPPs described in the literature have shown disparate cytogenetic information. This is the first report of a normal chromosome complement in atypical CPP. The heterogenic genetic features observed in these small series may reflect the diverse genetic background of choroid plexus tumors in children.
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