Resolution of syringomyelia and Chiari malformation after growth hormone therapy

Introduction The association between hypopituitarism, Chiari I malformation, and syringomyelia has been recently recognized. Most of the reported patients suffered perinatal injury or asphyxia. Materials and methods We present the case of a premature child without identifiable perinatal injury, who was recognized to have growth hormone (GH) deficiency, Chiari I malformation, and syringohydromyelia. Conclusion There was a resolution of syrinx and tonsillar herniation after GH replacement.