Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 28, Pages 8124-8128Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501779
Keywords
bioluminescence; bioorganic chemistry; biosynthesis; luciferin; natural products
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Funding
- Russian Science Foundation [14-50-00131]
- Russian Science Foundation [14-50-00131] Funding Source: Russian Science Foundation
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Many species of fungi naturally produce light, a phenomenon known as bioluminescence, however, the fungal substrates used in the chemical reactions that produce light have not been reported. We identified the fungal compound luciferin 3-hydroxyhispidin, which is biosynthesized by oxidation of the precursor hispidin, a known fungal and plant secondary metabolite. The fungal luciferin does not share structural similarity with the other eight known luciferins. Furthermore, it was shown that 3-hydroxyhispidin leads to bioluminescence in extracts from four diverse genera of luminous fungi, thus suggesting a common biochemical mechanism for fungal bioluminescence.
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