Journal
CHEST
Volume 138, Issue 5, Pages 1078-1085Publisher
AMER COLL CHEST PHYSICIANS
DOI: 10.1378/chest.09-2002
Keywords
-
Categories
Funding
- Actelion
Ask authors/readers for more resources
Objective: Pulmonary hypertension (PH) has been associated with increased mortality in patients with advanced pulmonary sarcoidosis. Sarcoidosis-associated PH may be the result of left ventricular dysfunction (LVD) or isolated pulmonary vasculature abnormality. Our objective was to determine if the cause of PH affects survival in patients with sarcoidosis with persistent dyspnea. Methods: Patients with sarcoidosis with persistent dyspnea despite immunosuppressive therapy underwent right-sided heart catheterization. Patients with a pulmonary artery occluding pressure (PAO) >= 15 mm Hg were defined as having LVD. Patients were classified based on hemodynamics as no PH (pulmonary, artery mean pressure [PAmean] <25 mm Hg), PH without LVD (PAmean >= 25 mm Hg and PAO <15 mm Hg), and PH with LVD (PH/LVD) (PAmean >= 25 mm Hg and PAO >= 15 mm Hg). Results: One hundred thirty patients were studied at one institution: 50 (38.5%) patients had PH without LVD, whereas 20 (15.4%) had PH/LVD. All patients had their diagnostic procedure at least 18 months prior to analysis. The hazard ratio (HR) for death in PH without LVD vs no PH was 10.39 (95% CI, 2.99-13.78; P<.0001). The HR for dying for PH without LVD vs PH/LVD was 3.14(95% CI, 1.01-5.62; P<.05). The presence of stage 4 chest roentgenograms and the need for supplemental oxygen were different between the groups. In a Cox proportional hazards model, independent predictors for survival were stage 4 chest roentgenogram (P<.005) and hemodynamic group (P<.02). Conclusion: PH without LVD was associated with of patients required hemodynamic evaluation, as LVD. increased mortality. Proper characterization 29% of sarcoidosis-associated PH was due to CHEST 2010; 138(5):1078-1085
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available