Journal
CHEST
Volume 138, Issue 6, Pages 1316-1321Publisher
ELSEVIER SCIENCE BV
DOI: 10.1378/chest.09-2708
Keywords
-
Categories
Funding
- electromagnetic navigation bronchoscopy
Ask authors/readers for more resources
Background Electromagnetic navigation bronchoscopy (ENB) has been developed as a novel ancillary tool for the bronchoscope diagnosis of pulmonary nodules Despite successful navigation in 90% of patients, ENB diagnostic yield does not generally exceed 70% We sought to determine whether the presence of a bronchus sign on CT imaging conditions diagnostic yield of ENB and might account for the discrepancy between successful navigation and diagnostic yield Methods We conducted a prospective, single-center study of ENB in 51 consecutive patients with pulmonary nodules ENB was chosen as the least invasive diagnostic technique in patients with a high surgical risk, suspected metastatic disease, or advanced-stage disease, or in those who demanded a preoperative diagnosis prior to undergoing curative resection We studied patient and technical variables that might condition diagnostic yield, including size, cause, location, distance to the pleural surface, and fluorodeoxyglucose uptake of a given nodule, the presence of a bronchus sign on CT imaging, registration point divergence, and the minimum distance from the tip of the locatable guide to the nodule measured during the procedure Results The diagnostic yield of ENB was 67% (34/51) The sensitivity and specificity of ENB for malignancy in this study were 71% and 100%, respectively ENB was diagnostic in 79% (30/38) patients with a bronchus sign on CT imaging but only in 4/13 (31%) with no discernible bronchus sign Univariate analysis identified the bronchus sign (P = 005) and nodule size (P = 04) as statistically significant variables conditioning yield, but on multivariate analysis, only the bronchus sign remained significant (OR, 7 6, 95% CI, 1 8-31 7) No procedure-related complications were observed Conclusions ENB diagnostic yield is highly dependent on the presence of a bronchus sign on CT imaging CHEST 2010, 138(6) 1316-1321
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available