Journal
CHEST
Volume 138, Issue 6, Pages 1456-1463Publisher
ELSEVIER
DOI: 10.1378/chest.10-0366
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Funding
- National Heart Lung and Blood Institute/National Institutes of Health [K24 HL004074]
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After more than a century of relying on skin testing for the diagnosis of latent TB infection, clinicians now have access to blood-based diagnostics in the form of interferon gamma release assays (IGRAs) These tests are generally associated with higher sensitivity and specificity for diagnosis of latent TB infection This article reviews the indications for testing and treatment of latent TB infection in the overall context of a TB control program and describes how IGRAs might be used in specific clinical settings and populations, including people having close contact with an active case of TB, the foreign born, and health-care workers CHEST 2010, 138(6) 1456-1463
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