Journal
CHEST
Volume 135, Issue 2, Pages 492-498Publisher
ELSEVIER
DOI: 10.1378/chest.08-1391
Keywords
bronchodilator response; occupational lung disease; spirometry; weight gain; World Trade Center
Categories
Funding
- ALLCDC
- NIOSH [3U10OH008239-04S2, 557746, 553948, 568749] Funding Source: Federal RePORTER
- NIOSH
- ALLCDC [3U10OH008239-05S1, 3U10OH008239-05S5] Funding Source: Federal RePORTER
- PHS HHS [5U1O 0H008232] Funding Source: Medline
- NIOSH CDC HHS [U10 OH008223, U10 OH008239, U10 OH008225, U10 OH008275, U10 OH008216] Funding Source: Medline
Ask authors/readers for more resources
Background: Multiple studies have demonstrated an initial high prevalence of spirometric abnormalities following World Trade Center (WTC) disaster exposure. We assessed prevalence of spirometric abnormalities and changes in spirometry between baseline and first follow-up evaluation in participants in the WTC Worker and Volunteer Medical Monitoring Program. We also determined the predictors of spirometric change between the two examinations. Methods: Prebronchodilator and postbronchodilator spirometry, demographics, occupational history, smoking status, and respiratory symptoms and exposure onset were obtained at both P examinations (about 3years apart). Results: At the second examination, 24.1% of individuals had abnormal spirometry findings. The predominant defect was a low FVC without obstruction (16.1%). Between examinations, the majority of individuals did not have a greater-than-expected decline in lung function. The mean declines in prebronchodilator FEV1, and FVC were 13 mL/yr and 2 mL/yr, respectively (postbronchodilator results were similar and not reported). Significant predictors of greater average decline between examinations were bronchodilator responsiveness at examination 1 and-weight gain. Conclusions: Elevated rates of spirometric abnormalities were present at both examinations, with reduced FVC most common. Although the majority had a normal decline in lung function, initial bronchodilator response and weight gain were significantly associated with greater-than-normal lung function declines. Due to the presence of spirometric abnormalities > 5 years after the disaster in many exposed individuals, longer-term monitoring of WTC responders is essential. (CHEST 2009; 135:492-498)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available