Journal
CHEMSUSCHEM
Volume 5, Issue 2, Pages 320-325Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201100570
Keywords
aldol reaction; continuous flow; heterogeneous catalysis; organocatalysis; supported catalysts
Funding
- MICINN [CTQ2008-00947/BQU]
- Consolider Ingenio [CSD2006-0003]
- DIUE [2009SGR623]
- ICIQ Foundation
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Asymmetric aldol reactions catalyzed by a novel polystyrene-immobilized proline derivative occur in short reaction times with excellent diastereo- and enantioselectivity. The catalyst can be recovered by simple filtration and shows very high reusability. The high activity depicted by the supported catalyst and its chemical and mechanical stability have allowed its application in packed-bed reactors for continuous flow processing. This system can produce enantio- and diastereomerically pure aldol adducts under continuous flow conditions with a residence time of 26 min. Furthermore, the reactor allowed processing of four different aldol products in sequence without any decrease in both catalytic activity and optical purity. The effective catalyst loading could be reduced to 1.6?% (six-fold reduction of catalyst loading compared to the corresponding batch process).
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