Journal
CHEMPHYSCHEM
Volume 11, Issue 3, Pages 585-589Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.200900743
Keywords
biosensors; conducting materials; molecular devices; nanocomposites; nanomaterials
Funding
- NNSFC [10674746, 70825520]
- NBRPC [2007CB936000, 2070CB934504]
- Ministry of Health [2009ZX10004-301]
- Chinese Academy of Sciences
- Shanghai Supercomputer Center of China
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Based on numerical simulations and experimental studies, we show that a composite material which consists of a sheet of graphene on a Au(111) surface exhibits both an excellent conductivity and the ability to stably adsorb biomolecules. If we use this material as a substrate, the signal-to-noise ratios can be greatly enhanced. The key to this unique property is that graphene can stably adsorb carbon-based rings, which are widely present in biomolecules, due to pi-stacking interactions while the substrate retains the excellent conductivity of gold. Remarkably, the signal-to-noise ratio is found to be so high that the signal is clearly distinguishable for different nucleobases when an ssDNA is placed on this graphene-on-Au(111) material. Our finding opens opportunities for a range of bio/nano-applications including sing le-DNA-molecule-based biodevices and biosensors, particularly, high-accuracy sequencing of DNA strands with repeating segments.
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