Journal
CHEMOTHERAPY
Volume 56, Issue 6, Pages 492-500Publisher
KARGER
DOI: 10.1159/000321018
Keywords
Multidrug resistance; Gram-negative bacilli; Pseudomonas; Enterobacteriaceae; Acinetobacter
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The increasing emergence of serious multidrug-resistant (MDR) Gram-negative infections has led to a new health-care crisis. These infections predominately include MDR Pseudomonas aeruginosa, extended-spectrum beta-lactamase-producing Enterobacteriaceae and MDR Acinetobacter baumannii. These organisms are present in a variety of clinical settings, but there is a distinct paucity of antibiotics to effectively treat these infections. The increasing use of broad-spectrum antibiotics and lack of good stewardship have contributed to the increase in these MDR organisms. This review focuses on the main MDR Gram-negative infections contributing to the current crisis in health care, their mechanisms of resistance and various treatment options for empiric therapy. Copyright (C) 2010 S. Karger AG, Basel
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