Adsorption and breakdown of penicillin antibiotic in the presence of titanium oxide nanoparticles in water

The fate and transport of antibiotics in natural water systems is controlled in part by interactions with nanometer (10(-9) m) metal oxide particles. Experiments were performed by mixing solutions of ampicillin (AMP), a common, penicillin-class human and veterinary antibiotic, with 25 nm-TiO2 (anatase) nanoparticles at different pH conditions. Both sorption and degradation of AMP were observed in the AMP-nanoparticle solutions. For AMP concentrations from similar to 3 mu M to 2.9 mM the overall AMP removal from solution can be described by linear isotherms with removal coefficients (K-r) of 3028 (+/- 267) L kg(-1) at pH 2, 11,533 (+/- 823) L kg(-1) at pH 4, 12,712 (+/- 672) L kg(-1) at pH 6, and 1941 (+/- 342) L kg(-1) at pH 8. Mass spectral analysis of AMP solutions after removal of the solid nanoparticles yielded ions that indicate the presence of peniclloic acid, penilloic acid and related de-ammoniated by-products as possible compounds resulting from the degradation of AMP at the TiO2 surface. (C) 2012 Elsevier Ltd. All rights reserved.