Journal
CHEMOSPHERE
Volume 79, Issue 9, Pages 953-957Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2010.02.032
Keywords
Mixture toxicity; Springtails; Heavy metal; Insecticide
Categories
Funding
- EU [003956]
Ask authors/readers for more resources
Two reference models are commonly used to predict mixture toxicity, Concentration Addition and Independent Action. For accurately predicting mixture effects, both reference models need a full description of the dose-response curve for all single chemicals present in the mixture. We studied the mixture effect of nickel and chlorpyrifos on survival of the soil-dwelling collembolan Folsomia candida exposed for 7 weeks in Lufa 2.2 soil. Especially chlorpyrifos toxicity showed extremely steep dose-response curves, making it impossible to fulfil the assumptions required by both reference models. Nevertheless, we showed that by monitoring the development of toxicity in time for both the single compounds and the mixtures it was possible to determine mixture effects. Even at exposure levels below the No Effect Concentration, chlorpyrifos was found to reduce nickel toxicity. In addition, this study clearly showed that toxicity is a dynamic process and that mixture effects may be dependent on exposure time. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available