Journal
CHEMMEDCHEM
Volume 13, Issue 20, Pages 2159-2165Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201800492
Keywords
amino acids; decarboxylative coupling; DNA; photoredox catalysis; radical reactions
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Funding
- Pfizer Inc.
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A new procedure for the photoredox-mediated conjugate addition of radicals that can be conveniently generated from -amino acids to DNA-tagged Michael acceptors and styrenes is presented. This C(sp(3))-C(sp(3)) coupling tolerates a broad array of structurally diverse radical precursors, including all of the 20 proteinogenic amino acids. Importantly, this reaction proceeds under mild conditions and in DNA-compatible aqueous media. Furthermore, the presented reaction conditions are compatible with DNA, making this reaction platform well suited for the construction of DNA-encoded libraries. The scope and limitations of the chemistry are discussed herein along with proposals for how this methodology might be used to construct DNA-encoded libraries.
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