Related references
Note: Only part of the references are listed.Identification of novel SIRT2-selective inhibitors using a click chemistry approach
Prima R. Tatum et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Development and characterization of 3-(benzylsulfonamido) benzamides as potent and selective SIRT2 inhibitors
Mohammad A. Khanfar et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
New assays and approaches for discovery and design of Sirtuin modulators
Mike Schutkowski et al.
EXPERT OPINION ON DRUG DISCOVERY (2014)
A Novel Sirtuin 2 ( SIRT2) Inhibitor with p53-dependent Pro- apoptotic Activity in Non- small Cell Lung Cancer*
Gesine Hoffmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Discovery of Potent and Selective Sirtuin 2 (SIRT2) Inhibitors Using a Fragment-Based Approach
Huaqing Cui et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Structural and Functional Analysis of Human SIRT1
Andrew M. Davenport et al.
JOURNAL OF MOLECULAR BIOLOGY (2014)
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism
Giang Thi Tuyet Nguyen et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)
Crystal Structures of Sirt3 Complexes with 4′-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism
Giang Thi Tuyet Nguyen et al.
CHEMISTRY & BIOLOGY (2013)
Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
Jessica L. Feldman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1-3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells
Paolo Mellini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Discovery of Thieno[3,2-4-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
Jeremy S. Disch et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Crystal structure analysis of human Sirt2 and its ADP-ribose complex
Sebastien Moniot et al.
JOURNAL OF STRUCTURAL BIOLOGY (2013)
SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase
Gaelle Laurent et al.
MOLECULAR CELL (2013)
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Hong Jiang et al.
NATURE (2013)
Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?
Ian F. Harrison et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
Melanie Gertz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
3-(N-Arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2)
Soo Hyuk Choi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
ZINC: A Free Tool to Discover Chemistry for Biology
John J. Irwin et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors
Takayoshi Suzuki et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Assessment of a Rule-Based Virtual Screening Technology (INDDEx) on a Benchmark Data Set
Christopher R. Reynolds et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2012)
Are sirtuins viable targets for improving healthspan and lifespan?
Joseph A. Baur et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
F. Wang et al.
ONCOGENE (2012)
Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition
Frank Fischer et al.
PLOS ONE (2012)
The discovery of novel 10,11-dihydro-5H-dibenz[b,f]azepine SIRT2 inhibitors
Paolo Di Fruscia et al.
MEDCHEMCOMM (2012)
Inhibition of SIRT2 Potentiates the Anti-motility Activity of Taxanes: Implications for Antineoplastic Combination Therapies
Katiuscia Bonezzi et al.
NEOPLASIA (2012)
A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase
David M. Taylor et al.
ACS CHEMICAL BIOLOGY (2011)
Structure-based development of novel sirtuin inhibitors
Christine Schlicker et al.
AGING-US (2011)
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
Dante Rotili et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity
Hyun-Seok Kim et al.
CANCER CELL (2011)
SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis
Yanze Li et al.
GENES TO CELLS (2011)
Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)
Thomas Pesnot et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats
Elzbieta Lorenc-Koci et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
Bogdan Beirowski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Jintang Du et al.
SCIENCE (2011)
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease
Anthony C. Vernon et al.
BMC NEUROSCIENCE (2010)
SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology
Kai Harting et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2010)
Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)
Kilian Huber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan B. Baell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
Barrie Peck et al.
MOLECULAR CANCER THERAPEUTICS (2010)
NAD+-Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets
Joerg Schemies et al.
MEDICINAL RESEARCH REVIEWS (2010)
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Ruth Luthi-Carter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A continuous microplate assay for sirtuins and nicotinamide-producing enzymes
Brian C. Smith et al.
ANALYTICAL BIOCHEMISTRY (2009)
Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity
Yingjia Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest
Toshiaki Inoue et al.
CELL CYCLE (2009)
Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes
Lei Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Structural and Synthetic Investigations of Tanikolide Dimer, a SIRT2 Selective Inhibitor, and Tanikolide seco-Acid from the Madagascar Marine Cyanobacterium Lyngbya majuscula
Marcelino Gutierrez et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
Recent progress in the biology and physiology of sirtuins
Toren Finkel et al.
NATURE (2009)
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
E. Lara et al.
ONCOGENE (2009)
Nigral Degeneration with Inclusion Body Formation and Behavioral Changes in Rats after Proteasomal Inhibition
Chaoshi Niu et al.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY (2009)
Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents
Paul A. Johnston et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2008)
Biological and Potential Therapeutic Roles of Sirtuin Deacetylases
D. M. Taylor et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
The Sirtuin family: therapeutic targets to treat diseases of aging
Jill C. Milne et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
Robert C. Neugebauer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Neutral red uptake assay for the estimation of cell viability/cytotoxicity
Guillermo Repetto et al.
NATURE PROTOCOLS (2008)
Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (Sirtuins)
Johannes Trapp et al.
CHEMMEDCHEM (2007)
Sirtuins: critical regulators at the crossroads between cancer and aging
L. R. Saunders et al.
ONCOGENE (2007)
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
Fei Wang et al.
AGING CELL (2007)
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
Enxuan Jing et al.
CELL METABOLISM (2007)
Linking SIRT2 to Parkinson's disease
Adam L. Garske et al.
ACS CHEMICAL BIOLOGY (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
Sirtuins in mammals: insights into their biological function
Shaday Michan et al.
BIOCHEMICAL JOURNAL (2007)
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition
Johannes Trapp et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
Alejandro Vaquero et al.
GENES & DEVELOPMENT (2006)
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
B Heltweg et al.
CANCER RESEARCH (2006)
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
K Arnold et al.
BIOINFORMATICS (2006)
In vitro assays for the determination of histone deacetylase activity
B Heltweg et al.
METHODS (2005)
Mechanism of sirtuin inhibition by nicotinamide:: Altering the NAD+ cosubstrate specificity of a Sir2 enzyme
JL Avalos et al.
MOLECULAR CELL (2005)
Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
IV Gregoretti et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
SC Dryden et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Histone deacetylases (HDACs): characterization of the classical HDAC family
AJM De Ruijter et al.
BIOCHEMICAL JOURNAL (2003)
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
BJ North et al.
MOLECULAR CELL (2003)
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2 '-O-acetyl ADP ribose and histone peptide
KH Zhao et al.
STRUCTURE (2003)
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats
KS McNaught et al.
NEUROREPORT (2002)
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
KS McNaught et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
CM Grozinger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure of the histone deacetylase SIRT2
MS Finnin et al.
NATURE STRUCTURAL BIOLOGY (2001)
Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)
A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging
Sule Kocabas et al.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION