Journal
CHEMMEDCHEM
Volume 8, Issue 5, Pages 694-707Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201200560
Keywords
antitumor agents; autophagy; cancer; small-molecule regulators
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Funding
- Chinese National Natural Science Foundation [81172984, 21072213, 21002117, 21102168, 21102165]
- 863 High-Tech program from the Chinese Ministry of Science and Technology [2012AA020308]
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Autophagy is a highly conserved process in which damaged proteins and organelles are sequestered in double-membrane autophagosomes and delivered to lysosomes for degradation and recycling. As an efficient response to cellular stress, autophagy is essential for the maintenance of cellular homeostasis. Defective autophagy is associated with a variety of diseases, including cancer. This article summarizes current knowledge about the molecular mechanism of autophagy and its role in tumorigenesis. Particular focus is placed on the development of small-molecule regulators of autophagy and their potential application as anticancer therapeutic agents.
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