Related references
Note: Only part of the references are listed.Novel Schiff-Base-Derived FabH Inhibitors with Dioxygenated Rings as Antibiotic Agents
Yang Zhou et al.
CHEMMEDCHEM (2013)
Discovery of novel InhA reductase inhibitors: application of pharmacophore- and shape-based screening approach
Uday Chandra Kumar et al.
FUTURE MEDICINAL CHEMISTRY (2013)
In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics
Nachum Kaplan et al.
JOURNAL OF CHEMOTHERAPY (2013)
Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model
Mary A. Banevicius et al.
JOURNAL OF CHEMOTHERAPY (2013)
Panosialins, Inhibitors of Enoyl-ACP Reductase from Streptomyces sp AN1761
Yun Ju Kwon et al.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2013)
Structural Insights into the Mechanism and Inhibition of the β-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas aeruginosa
Lucile Moynie et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Structure of FabH and factors affecting the distribution of branched fatty acids in Micrococcus luteus
Jose H. Pereira et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
Purification, crystallization and preliminary X-ray diffraction analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus mutans strain UA159
Tae-O Kim et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2012)
Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor
Nachum Kaplan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Chalcomoracin and Moracin C, New Inhibitors of Staphylococcus aureus Enoyl-Acyl Carrier Protein Reductase from Morus alba
Yu Jin Kim et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2012)
Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors
Yao Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Yu-Shun Yang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375
Nyung Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Advances in the Research of β-Ketoacyl-ACP Synthase III (FabH) Inhibitors
H. -J. Zhang et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds
Pan Pan et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Design, synthesis and antibacterial activities of vanillic acylhydrazone derivatives as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Xiao-Liang Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Discovery of a Novel and Potent Class of F. tularensis Enoyl-Reductase (FabI) Inhibitors by Molecular Shape and Electrostatic Matching
Kirk E. Hevener et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) Inhibitors
Shahila Mehboob et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
From Triclosan toward the Clinic: Discovery of Nonbiocidal, Potent FabI Inhibitors for the Treatment of Resistant Bacteria
Vincent Gerusz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Environmental DNA-Encoded Antibiotics Fasamycins A and B Inhibit FabF in Type II Fatty Acid Biosynthesis
Zhiyang Feng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis
Kirk E. Hevener et al.
PROTEIN EXPRESSION AND PURIFICATION (2012)
Crystal structure and fluorescence studies reveal the role of helical dimeric interface of staphylococcal fabg1 in positive cooperativity for NADPH
Debajyoti Dutta et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2012)
Structure of the Yersinia pestis FabV Enoyl-ACP Reductase and Its Interaction with Two 2-Pyridone Inhibitors
Maria W. Hirschbeck et al.
STRUCTURE (2012)
The MUT056399 Inhibitor of FabI Is a New Antistaphylococcal Compound
S. Escaich et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Discovery of vinylogous carbamates as a novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Huan-Qiu Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Synthesis, molecular modeling and biological evaluation of β-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents
Hong-Jia Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino)phenyl-N′-phenyl-thiourea
Hong-Jia Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors
Zi-Lin Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Dialkylamino-2,4-dihydroxybenzoic Acids as Easily Synthesized Analogues of Platensimycin and Platencin with Comparable Antibacterial Properties
Jingxin Wang et al.
CHEMISTRY-A EUROPEAN JOURNAL (2011)
Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?
Joshua B. Parsons et al.
CURRENT OPINION IN MICROBIOLOGY (2011)
Crystal Structures of Enoyl-ACP Reductases I (FabI) and III (FabL) from B. subtilis
Kook-Han Kim et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors
Joshua B. Parsons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Fatty acid biosynthesis in actinomycetes
Gabriela Gago et al.
FEMS MICROBIOLOGY REVIEWS (2011)
Triclosan Resistance of Pseudomonas aeruginosa PAO1 Is Due to FabV, a Triclosan-Resistant Enoyl-Acyl Carrier Protein Reductase
Lei Zhu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus
Su Jin Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Mechanism and Inhibition of the FabV Enoyl-ACP Reductase from Burkholderia mallei
Hao Lu et al.
BIOCHEMISTRY (2010)
Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics
Kui Cheng et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents
Huan-Qiu Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors
Peng-Cheng Lv et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers
Jingjing Yao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Syntheses and Antibacterial Properties of iso-Platencin, Cl-iso-Platencin and Cl-Platencin: Identification of a New Lead Structure
Konrad Tiefenbacher et al.
CHEMISTRY-A EUROPEAN JOURNAL (2010)
Design and synthesis of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents
Lei Shi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis
Sylvia R. Luckner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Methyl-Branched Fatty Acids, Inhibitors of Enoyl-ACP Reductase with Antibacterial Activity from Streptomyces sp A251
Zheng Chang Ji et al.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2010)
Essentiality of FASII pathway for Staphylococcus aureus
Wendy Balemans et al.
NATURE (2010)
Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan
Amit Priyadarshi et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
Slow-Onset Inhibition of the Fabl Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity
Hao Lu et al.
ACS CHEMICAL BIOLOGY (2009)
AFN-1252, a FabI Inhibitor, Demonstrates a Staphylococcus-Specific Spectrum of Activity
James A. Karlowsky et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Campylobacter jejuni fatty acid synthase II: Structural and functional analysis of β-hydroxyacyl-ACP dehydratase (FabZ)
Andrew S. Kirkpatrick et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Aquastatin A, a New Inhibitor of Enoyl-Acyl Carrier Protein Reductase from Sporothrix sp FN611
Yun-Ju Kwon et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)
Novel E-coli β-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics
Jee-Young Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics
Kui Cheng et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Synthesis of C(7) modified chrysin derivatives designing to inhibit β-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics
Huan-Qiu Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors
Peng-Cheng Lv et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Synthesis and biological evaluation of platensimycin analogs
Hong C. Shen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis
Sheo B. Singh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI
Jailall Ramnauth et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI)
Peter B. Sampson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Diversity in enoyl-acyl carrier protein reductases
R. P. Massengo-Tiasse et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme
Ketan S. Gajiwala et al.
FEBS LETTERS (2009)
Isolation, structure and biological activities of platensimycin B-4 from Streptomyces platensis
Chaowei Zhang et al.
JOURNAL OF ANTIBIOTICS (2009)
Vinaxanthone, a new FabI inhibitor from Penicillium sp.
Chang Ji Zheng et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2009)
Heterologous Expression of Mycobacterial Proteins in Saccharomyces cerevisiae Reveals Two Physiologically Functional 3-Hydroxyacyl-Thioester Dehydratases, HtdX and HtdY, in Addition to HadABC and HtdZ
Aner Gurvitz et al.
JOURNAL OF BACTERIOLOGY (2009)
Discovering Potent Inhibitors Against the β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) of Helicobacter pylori: Structure-Based Design, Synthesis, Bioassay, and Crystal Structure Determination
Lingyan He et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
Sophie Brinster et al.
NATURE (2009)
Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH
Qosay Al-Balas et al.
PLOS ONE (2009)
Molecular basis for triclosan activity involves a flipping loop in the active site
Xiayang Qiu et al.
PROTEIN SCIENCE (2009)
Natural product juglone targets three key enzymes from Helicobacter pylori:: inhibition assay with crystal structure characterization
Yun-hua Kong et al.
ACTA PHARMACOLOGICA SINICA (2008)
Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis
Edward Turos et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
Suresh K. Tipparaju et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors
Christopher W. am Ende et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B-1-B-3 from Streptomyces platensis
Chaowei Zhang et al.
CHEMICAL COMMUNICATIONS (2008)
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata
Anastasia Karioti et al.
PHYTOMEDICINE (2008)
Structure and semisynthesis of platensimide A, produced by Streptomyces platensis
Kithsiri B. Herath et al.
ORGANIC LETTERS (2008)
Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor
Jun Saito et al.
PROTEIN SCIENCE (2008)
Structure of homoplatensimide A:: a potential key biosynthetic intermediate of platensimycin isolated from Streptomyces platensis
Hiranthi Jayasuriya et al.
TETRAHEDRON LETTERS (2008)
Structural basis for catalytic and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ)
Liang Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A unique and differential effect of denaturants on cofactor mediated activation of Plasmadium falciparum β-ketoacyl-ACP reductase
Krishanpal Karmodiya et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
Vibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductase
R. Prisca Massengo-Tiasse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK
Tomohiro Ozawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005
Eili Klein et al.
EMERGING INFECTIOUS DISEASES (2007)
Crystal structure of the Helicobacter pylori enoyl-acyl carrier protein reductase in complex with hydroxydiphenyl ether compounds, triclosan and diclosan
Hyung Ho Lee et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
Cephalochromin, a FabI-directed antibacterial of microbial origin
Chang Ji Zheng et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli
Deniz Tasdemir et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
CG400462, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor
Hee Soo Park et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2007)
Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA)
Peter C. Appelbaum
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2007)
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides
Xin Hea et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Anthecularin:: A novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity
Anastasia Karioti et al.
JOURNAL OF ORGANIC CHEMISTRY (2007)
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis:: Evaluation of a-ring-modified diphenyl ethers as high-affinity InhA inhibitors
Melissa E. Boyne et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein Reductases FabI and FabK
Hideo Kitagawa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis
Emmanuelle Sacco et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK
Hideo Kitagawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis
Kathleen Julian et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
X-ray structural analysis of plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of Triclosan antimalarial efficacy
Joel S. Freundlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Chemistry of platensimycin
Sheo B. Singh et al.
TETRAHEDRON LETTERS (2007)
Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth
Michael D. Wall et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Jun Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes
Marnoun M. Alhamadsheh et al.
CHEMISTRY & BIOLOGY (2007)
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis
Kook-Han Kim et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2007)
Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli β-ketoacyl-ACP-synthase III (FabH)
Mamoun M. Alhamadsheh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Discovery of 4-pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (Fabl) with antibacterial activity against Staphylococcus aureus
Sho Takahata et al.
JOURNAL OF ANTIBIOTICS (2007)
Emerging options for treatment of invasive, multidrug-resistant Staphylococcus aureus infections
Richard H. Drew
PHARMACOTHERAPY (2007)
Mechanism of thioamide drug action against tuberculosis and leprosy
Feng Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI
Hideo Kitagawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor
Hee Soo Park et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)
In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis
James A. Karlowsky et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Isolation and structure of platencin: A FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity
Hiranthi Jayasuriya et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae
Chang-Ji Zheng et al.
JOURNAL OF ANTIBIOTICS (2006)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Makoto Matsumoto et al.
PLOS MEDICINE (2006)
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
Xin He et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy
Sheo B. Singh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Analyses of co-operative transitions in Plasmodium falciparum β-ketoacyl acyl carrier protein reductase upon co-factor and acyl carrier protein binding
Krishanpal Karmodiya et al.
FEBS JOURNAL (2006)
Opinion - Drug-target residence time and its implications for lead optimization
Robert A. Copeland et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
AG205, a novel agent directed against FabK of Streptococcus pneumoniae
Sho Takahata et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration
Sakiko Inatsu et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Inhibition of Plasmodium falciparum fatty acid biosynthesis:: Evaluation of FabG, FabZ, and FabI as drug targets for flavonoids
Deniz Tasdemir et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Crystallization and preliminary X-ray analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae
Jun Saito et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2006)
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
J Wang et al.
NATURE (2006)
Antibiotic resistance in bacteria and its future for novel antibiotic development
Hiroshi Yoneyama et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2006)
Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori
BS Park et al.
JOURNAL OF ETHNOPHARMACOLOGY (2006)
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity
R Theodori et al.
JOURNAL OF NATURAL PRODUCTS (2006)
MRSA - the tip of the iceberg
PC Appelbaum
CLINICAL MICROBIOLOGY AND INFECTION (2006)
Antibacterial drug discovery - Then, now and the genomics future
RL Monaghan et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Use of genomics to select antibacterial targets
MJ Pucci
BIOCHEMICAL PHARMACOLOGY (2006)
Discovery of FabH/FabF inhibitors from natural products
K Young et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Structure-activity relationships at the 5-position of thiolactomycin:: An intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli
P Kim et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria
BH Li et al.
IUBMB LIFE (2006)
High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis
Todd J. Sullivan et al.
ACS CHEMICAL BIOLOGY (2006)
The crystal structure of PfFabZ, the unique β-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum
D Kostrewa et al.
PROTEIN SCIENCE (2005)
The first chemical synthesis of the core structure of the benzoylhydrazine-NAD adduct, a competitive inhibitor of the Mycobacterium tuberculosis enoyl reductase
S Broussy et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
XY Qiu et al.
PROTEIN SCIENCE (2005)
Novel target sites in bacteria for overcoming antibiotic resistance
MT Black et al.
ADVANCED DRUG DELIVERY REVIEWS (2005)
Structure-based design, synthesis, and study of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
Z Nie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Ainti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots
D Tasdemir et al.
PHYTOCHEMISTRY (2005)
Antibiotics: Actions, origins, resistance, by C. Walsh. 2003. Washington, DC: ASM Press. 345 pp. $99.95 (hardcover).
Hans Von Döhren
PROTEIN SCIENCE (2004)
Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase
LL Ling et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG
AC Price et al.
STRUCTURE (2004)
Isolation and characterization of β-ketoacyl-acyl carrier protein reductase (fabG) mutants of Escherichia coli and Salmonella enterica serovar typhimurium
CY Lai et al.
JOURNAL OF BACTERIOLOGY (2004)
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis
JS Oliveira et al.
CHEMICAL COMMUNICATIONS (2004)
Inhibition of the bacterial enoyl reductase FabI by triclosan: A structure-reactivity analysis of FabI inhibition by triclosan analogues
S Sivaraman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme
SJ Senior et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues
HH Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases
SC Dillon et al.
BMC BIOINFORMATICS (2004)
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)
X He et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa
MS Kimber et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase
YM Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Antibacterial resistance worldwide: causes, challenges and responses
SB Levy et al.
NATURE MEDICINE (2004)
Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant:: A proposed mechanism for drug resistance
II Protasevich et al.
BIOCHEMISTRY (2004)
A stereoselective synthesis for the (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid and its monounsaturated analog (Z)-14-methyl-9-pentadecenoic acid
NM Carballeira et al.
TETRAHEDRON LETTERS (2004)
β-ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis
CY Lai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification, characterization, and inhibition of Plasmodium falciparum β-hydroxyacyl-acyl carrier protein dehydratase (FabZ)
SK Sharma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme
SJ Senior et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Where will new antibiotics come from?
C Walsh
NATURE REVIEWS MICROBIOLOGY (2003)
Targeting tuberculosis and malaria through inhibition of enoyl reductase
MR Kuo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK
MA Seefeld et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan:: Kinetic analysis of mutant
S Sivaraman et al.
BIOCHEMISTRY (2003)
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK)
H Marrakchi et al.
BIOCHEMICAL JOURNAL (2003)
Short-chain dehydrogenases/reductases (SDR): the 2002 update
U Oppermann et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2003)
Bacterial β-ketoacyl-acyl carrier protein synthases as targets for antibacterial agents
SS Khandekar et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2003)
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling
RA Daines et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum
RF Waller et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Discovery of a novel and potent class of fabI-directed antibacterial agents
DJ Payne et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
One fold with many functions: The evolutionary relationships between TIM barrel families based on their sequences, structures and functions
N Nagano et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)
WH Miller et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis
M Cohen-Gonsaud et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against β-lactamase-producing strains
Q Li et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
Purification, characterization, and identification of novel inhibitors of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
X He et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
Forty years of bacterial fatty acid synthesis
CO Rock et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase
R Perozzo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II
H Marrakchi et al.
MICROBIOLOGY-SGM (2002)
Lipid biosynthesis as a target for antibacterial agents
RJ Heath et al.
PROGRESS IN LIPID RESEARCH (2001)
Structure of β-ketoacyl-[acyl carrier protein] reductase from Escherichia coli:: Negative cooperativity and its structural basis
AC Price et al.
BIOCHEMISTRY (2001)
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI):: 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents
MA Seefeld et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
1,4-disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
DA Heerding et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae β-ketoacyl-acyl carrier protein synthase III (FabH)
SS Khandekar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Refined structures of β-ketoacyl-acyl carrier protein synthase III
XY Qiu et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Inhibition of β-ketoacyl-acyl carrier protein syntheses by thiolactomycin and cerulenin -: Structure and mechanism
AC Price et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery
JW Campbell et al.
ANNUAL REVIEW OF MICROBIOLOGY (2001)
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis
RJ Heath et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A triclosan-resistant bacterial enzyme (vol 406, pg 145, 2000)
RJ Heath et al.
NATURE (2000)
The X-ray structure of Brassica napus β-keto acyl carrier protein reductase and its implications for substrate binding and catalysis
M Fisher et al.
STRUCTURE (2000)
The 1.8 Å crystal structure and active-site architecture of β-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli
C Davies et al.
STRUCTURE (2000)
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis
KH Choi et al.
JOURNAL OF BACTERIOLOGY (2000)
Share Paper
