Related references
Note: Only part of the references are listed.Falcipain Inhibition as a Promising Antimalarial Target
Maria Marco et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Global malaria mortality between 1980 and 2010: a systematic analysis
Christopher J. L. Murray et al.
LANCET (2012)
Antimalarial peroxides: advances in drug discovery and design
Rachel D. Slack et al.
MEDCHEMCOMM (2012)
Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy
Rita Capela et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite
Sumit S. Mahajan et al.
CHEMMEDCHEM (2011)
Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
Connor O'Brien et al.
CURRENT OPINION IN INFECTIOUS DISEASES (2011)
Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent Chemical Probes
Carmony L. Hartwig et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine
Fatima Bousejra-El Garah et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities
Francesc Marti et al.
MEDCHEMCOMM (2011)
Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins
Paul M. O'Neill et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity
Peter Gibbons et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Artemisinin resistance: current status and scenarios for containment (vol 8, pg 272, 2010)
Arjen M. Dondorp et al.
NATURE REVIEWS MICROBIOLOGY (2010)
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition
Rita Capela et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Pharmacokinetics and Pharmacodynamics of Endoperoxide Antimalarials
Anirudh Gautam et al.
CURRENT DRUG METABOLISM (2009)
Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity
Lain D. Kerr et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Artemisinin Resistance in Plasmodium falciparum Malaria.
Arjen M. Dondorp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Broadly Applicable Synthesis of-1,2,4,5-Tetraoxanes.
Prasanta Ghorai et al.
ORGANIC LETTERS (2009)
Hybrid molecules with a dual mode of action: Dream or reality?
Bernard Meunier
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles
Gemma L. Ellis et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane Antimalarials
Igor Opsenica et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Malaria combination therapies: Advantages and shortcomings
A. Martinelli et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)
Selection of a trioxaquine as an antimalarial drug candidate
Frederic Cosledan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane Antimalarials
Darren J. Creek et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2007)
Peroxide bond-dependent antiplasmodial specificity of arternisinin and OZ277 (RBx11160)
Marcel Kaiser et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
Paul A. Stocks et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
Puran S. Sijwali et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2006)
Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery
Manoj K. Ramjee et al.
BIOCHEMICAL JOURNAL (2006)
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin
Richard Amewu et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2006)
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes
YX Dong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: Mechanistic comparators for artemisinin in the context of reaction pathways with iron(II)
YQ Tang et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Synthesis of tetrasubstituted ozonides by the griesbaum coozonolysis reaction: Diastereoselectivity and functional group transformations by post-ozonolysis reactions
YQ Tang et al.
JOURNAL OF ORGANIC CHEMISTRY (2004)
A medicinal chemistry perspective on artemisinin and related endoperoxides
PM O'Neill et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones
BR Shenai et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)