Journal
CHEMMEDCHEM
Volume 8, Issue 11, Pages 1818-1829Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201300295
Keywords
antioxidants; chelation therapy; glutathione; 8-hydroxyquinolines; neurodegenerative diseases; peptides
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Funding
- Italian Ministry for Education, University and Research (MIUR)
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Metal-ion dysregulation and oxidative stress have been linked to the progressive neurological decline associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Herein we report the synthesis and chelating, antioxidant, and in vitro neuroprotective activities of a novel derivative of glutathione, GS(HQ)H, endowed with an 8-hydroxyquinoline group as a metal-chelating moiety. In vitro results showed that GS(HQ)H may be stable enough to be absorbed unmodified and arrive intact to the blood-brain barrier, that it may be able to remove Cu-II and Zn-II from the A peptide without causing any copper or zinc depletion in vivo, and that it protects SHSY-5Y human neuroblastoma cells against H2O2- and 6-OHDA-induced damage. Together, these findings suggest that GS(HQ)H could be a potential neuroprotective agent for the treatment of neurodegenerative diseases in which a lack of metal homeostasis has been reported as a key factor.
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