Journal
CHEMMEDCHEM
Volume 7, Issue 7, Pages 1161-1172Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201200156
Keywords
biological activity; FtsZ; inhibitors; mechanisms of action; synthetic methods
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Funding
- National Natural Science Foundation of China [20872081, 21072114]
- Natural Science Foundation of Shandong [ZR2010HM092]
- SRF for ROCS, SEM
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The emergence and prevalence of bacterial resistance has resulted in a clear demand for novel antibacterial drugs. As a tubulin homologue, FtsZ is an essential cell-division protein in prokaryotic organisms and is showing increasing promise as a target for antibacterial drug discovery. This review describes the role of FtsZ in bacterial cytokinesis and various FtsZ inhibitors, with particular focus on their discovery, antibacterial activities, mechanisms of action, synthetic methods, and representative analogues.
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