Journal
CHEMMEDCHEM
Volume 6, Issue 3, Pages 399-409Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201000534
Keywords
biological activity; cancer; chemical synthesis; marine macrolides; mechanism of action
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Funding
- National Natural Science Foundation of China [20872081, 21072114]
- Major R&D Program of New Drugs-National S&T Key Special Subject of China [2009ZX09103-115]
- Natural Science Foundation of Shandong [ZR2010M092]
- SRF for ROCS, SEM
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Marine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various molecular targets. In particular, the marine macrolides, which include an array of novel biomolecules endowed with outstanding cytotoxic and/or anti-proliferative activities, are a prominent class of marine natural products that offer continued promise for breakthroughs in anticancer research. Herein we highlight some recent studies of promising marine macrolides, paying particular attention to their discovery, anticancer activities, mechanisms of action, chemical synthesis, and representative analogues.
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