Journal
CHEMMEDCHEM
Volume 6, Issue 11, Pages 2003-2008Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201100311
Keywords
antitumor agents; docetaxel; gold; nanoparticles; vectorization
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Funding
- University Bordeaux I
- Agence Nationale pour la Recherche (ANR)
- Centre National de la Recherche Scientifique (CNRS)
- Bergonie Institute of Bordeaux
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Encapsulation of docetaxel and its solubilization in water was carried out in PEGylated gold nanoparticles (AuNPs) as shown by H-1 NMR (600 MHz) and UV/Vis spectroscopy and dynamic light scattering. Vectorization of PEGylated AuNP-encapsulated docetaxel was probed in vitro toward human colon carcinoma (HCT15) and human breast cancer (MCF7) cells. AuNPs alone presented no cytotoxicity toward either MCF7 or HCT15 adenocarcinoma cells. AuNP-docetaxel was found to be 2.5-fold more efficient than docetaxel alone against MCF7 cells, and the IC50 value of AuNP-docetaxel against HCT15 cells was lower than that of free docetaxel; the increased efficiency brought about by AuNP drug encapsulation was similar to 1.5-fold.
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