Journal
CHEMMEDCHEM
Volume 5, Issue 11, Pages 1813-1824Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201000289
Keywords
AIDS; antiviral agents; cell-cell fusion; fusion inhibitors; gp41; HIV
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Funding
- US NIH [R01 AI46221, U19 AI76964]
- Beijing Institute of Pharmacology Toxicology
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It has been 25 years since the development of the first efficient HIV-1/AIDS treatment. Scientists now know more about the HIV-1 infection life cycle, and more than 30 antiretroviral drugs have been developed, including HIV-1 fusion inhibitors. Fundamental work was begun in the early 1990s and led to the development of a novel class of anti-HIV-1 drugs, culminating in a peptide known as T20, which is currently the only HIV-1 fusion inhibitor approved by the US Food and Drug Administration. However, more work needs to be done to perfect the development of peptide and small-molecule HIV fusion inhibitors, particularly those that target gp41. Herein we present a brief overview of the development of this class of anti-HIV-1 drug by focusing on the achievements, challenges, and lessons learned. We cite hallmark studies of the past and comment on future drug development.
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