Journal
CHEMMEDCHEM
Volume 4, Issue 3, Pages 310-323Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200800353
Keywords
antimycotic agents; azoles; calcineurins; echinocandins; medicinal chemistry; polyenes; vaccines
Categories
Funding
- University of Delhi
- CSIR, India
Ask authors/readers for more resources
Invasive fungal infections with primary and opportunistic mycoses have become increasingly common in recent years and pose a major diagnostic and therapeutic challenge. they represent a major area of concern in today's medical fraternity. The occurrence of invasive fungal disease, particularly in AIDS and other immunocompromised patients, is life-threatening and increases the economic burden. Apart from the previously known polyenes and imidazole-based azoles, newly discovered triazoles and echinocandins are more effective in terms of specificity, yet some immunosuppressed hosts are difficult to treat. The main reasons for this include antifungal resistance, toxicity, lack of rapid and microbe-specific diagnoses, poor penetration of drugs into sanctuary sites, and lack of oral or intravenous preparations. In addition to combination antifungal therapy, other novel antimycotic treatments such as calcineurin signaling pathway blockers and vaccines have recently emerged. This review briefly summarizes recent developments in the pharmacotherapeutic treatment of invasive fungal infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available