Journal
CHEMMEDCHEM
Volume 4, Issue 5, Pages 761-768Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200800430
Keywords
antitumor agents; conjugates; docosahexaenoic acid; fatty acids; thymoquinones
Categories
Funding
- Deutsche Forschungsgemeinschaft [Scho 402/8-2]
Ask authors/readers for more resources
4-Acylhydrazones and 6-alkyl derivatives of thymoquinone (TQ) were tested for growth inhibition of human HL-60 leukemia, 518A2 melanoma, KB-V1/Nbl cervix, and MCF-7/Topo breast carcinoma cells. Unsaturated side chains conferred greater activities than equally long saturated chains. The number of C=C bonds was less decisive than chain length. The 6-hencosahexaenyl conjugate 3 e was most active in all resistant tumor cells, with IC(50) (72 h) values as low as 30 nm in MCF-7/Topo cells. The conjugates are likely to operate by mechanisms different from that of TQ. For instance, 3 e induced distinct caspase-independent apoptosis in HL-60 and 518A2 cells concomitant with a loss of mitochondrial membrane potential and a subsequent rise in the levels of reactive oxygen species.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available