Journal
CHEMMEDCHEM
Volume 4, Issue 5, Pages 719-731Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200900044
Keywords
microtubules; molecular modeling; paclitaxel; REDOR NMR; REDOR-taxol; T-taxol; tubulin
Categories
Funding
- National Institutes of Health [CA 103314, GM42798]
- National Science Foundation [PACI-MCA02N028]
- NATIONAL CANCER INSTITUTE [R01CA103314] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM042798] Funding Source: NIH RePORTER
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Paclitaxel is one of the most important chemotherapeutic drugs in the-fight against cancer. This minireview covers the recent advances in the study of the bioactive conformation of paclitaxel in tubulin/microtubules. The tubulin-bound structure of paclitaxel has been studied by means of photoaffinity labeling, cryo-electron microscopy, solid-state NMR, molecular modeling, MD simulations and the synthesis of conformationally restrained analogues and paclitaxel mimics. The bioactive conformation of paclitaxel is important since it could provide critical information that would allow the design of novel analogues with simpler structures and/or increased potency against cancer.
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